Associate Professor David Groth
- Immune disorders
- Neurological disorders
David’s interests lie in molecular genetics and immunogenetics. As a CHIRI researcher, he channels his expertise into studies of the molecular mechanisms of Alzheimer’s disease, the genetics of the skin condition psoriasis and the genetics of host parasite interactions.
David’s Alzheimer’s disease research is as part of a collaboration with Edith Cowan University’s Professor Ralph Martins and CHIRI’s Associate Professor Giuseppe Verdile and is focused on manipulating and reconstituting the components of the gamma secretase complex which are required for the production of the amyloid-beta peptide. These peptides are the major constituents of senile plaques in Alzheimer’s disease patients’ brains.
Another aspect of this work is determining the role microglial cells have in the Alzheimer’s Disease pathogenesis. David hopes the information derived from this research will help provide a pathway for the development of new preventions and treatments for the disease. His work on psoriasis involves determining the role of several genes in the aetiology and pathology of this chronic skin disease, which affects about five per cent of the general population and is associated with comorbidities such as diabetes and heart disease. David hopes that this work will lead to a better understanding of the pathogenesis of psoriasis.
Research Interests – molecular genetics; population genetics; molecular immunogenetics; and molecular biology.