Dr Danielle Dye
- Immune disorders
Danielle’s research is about melanoma, muscle regeneration and unravelling the mechanisms behind these two very distinct areas of research. At CHIRI she works with Professor Deirdre Coombe and a research team keen to learn all there is to know about a somewhat mysterious protein called melanoma cell adhesion molecule (MCAM), which is present on the surface of most melanoma tumours and contributes to melanoma cell progression.
Danielle’s research focuses on what proteins MCAM interacts with, how it cycles to and from the cell surface and the mechanisms behind its pro-cancerous effects. The team hopes this information will shed light on how MCAM contributes to the proliferation, invasion and spread of melanoma cells.
Danielle’s other ‘detective’ work revolves around identifying factors that differ between young and old muscle in collaboration with colleagues at CHIRI. Healthy, young skeletal muscle is able to quickly regenerate following injury or overuse but this capacity decreases with age.
Loss of muscle mass in the elderly leads to an increased risk of impaired mobility and the ability to independently perform tasks. With muscle maintenance and regeneration known to be influenced by the environment surrounding each muscle fibre, Danielle and colleagues hope to use knowledge they uncover in their research to engineer scaffolds that stimulate new muscle formation. Long-term, their goal is to improve the treatment of muscle injury, diseased muscle and age-related muscle loss.
Research interests – melanoma, including how melanoma cell adhesion molecule contributes to the proliferation, invasion and metastasis of melanoma cells; muscle regeneration in ageing, including factors that differ between old and young muscle.