Dr Jose Caparros-Martin
- Vascular and metabolic disorders
Jose studies the human microbiome – a huge array of micro-organisms, including bacteria, fungi, viruses and other microbes, that live in and on our bodies. His main interest is researching the interaction between these microbes and their host to better understand how their genetic makeup shapes health and disease.
Part of Jose’s research looks at the impact of medicines on intestinal microbiota, which can cause their imbalance and impairment. Another avenue of his research seeks to identify host-derived factors that modulate the microbial communities in the lung.
Jose is part of a CHIRI-led research collaboration awarded a grant by Diabetes Research WA and the Endeavour College of Natural Health in late 2017 and 2018 respectively to mechanistically evaluate how the crosstalk host-gut microbiota can be modulated to prevent the development of metabolic disorders, such as cardiovascular disease.
A little more about his pre-CHIRI days – having completed his PhD at the Institute for Plant Molecular and Cell Biology in Spain, Jose worked as a scientist at the country’s Centre for Biomedical Network Research on Rare Diseases, before making the move to Australia in 2015.
Among Jose’s scientific achievements – he was involved in identifying mutations in three new genes as being the genetic cause of brittle bone disease, Osteogenesis imperfecta; a new causative gene of congenital multi-minicore myopathy; as well as specific variants in a new gene that causes the hereditary bone disorder Ellis-van Creveld syndrome, in humans. He also characterised the molecular mechanism through which the Ellis-van Creveld proteins Evc and Evc2 modulate the Hedgehog Signalling pathway.
Research interests – molecular and cell biology; molecular genetics; analysis of NGS data; microbiome analysis.