Dr Pat Metharom
- Vascular and metabolic disorders
- Inflammation, infectious disease and wounds
- Neurodegenerative disorders
Pat’s a scientist with a fundamental and translational research focus in platelet disorders. She heads the Platelet Research Laboratory which currently investigates the mechanisms, risk factors and treatments of cancer-associated thrombosis, or blood clots, which is a major cause of mortality in cancer patients.
With risk factors for developing thrombosis including the current chemotherapy-based treatments and immobilisation that often come with the disease, Pat’s intent on telling us more about the mechanisms that activate thrombosis in the hope of finding a way to counteract them.
Pat’s current studies focus on how platelets contribute to the progression of cancer and the release of neutrophil extracellular traps (NETs) – a mesh of DNA, proteins and enzymes that are a known host defence against pathogens but are also released in pathological conditions – which can activate platelets and promote thrombotic complications.
Pat is also heavily involved in research into the effects of Alzheimer’s disease-associated Amyloid-β peptides on platelet clumping in the formation of blood clots; and evaluating the validity of targeting platelets for the treatment of cancer.
Research interests – mechanisms, risk factors and treatments of cancer-associated thrombosis; Amyloid-β peptides in Alzheimer’s disease.