John Curtin Distinguished Professor John Mamo
- Vascular and metabolic disorders
- Neurodegenerative disorders
Director of CHIRI since September 2014, John is a physiologist known internationally for his lipoprotein and vascular kinetic studies in the context of heart disease and cerebro-vascular based disorders.
At CHIRI he leads a team of researchers whose hearts and minds are firmly set on finding better treatments for some serious neurodegenerative disorders, including dementia.
John’s laboratory was the first to demonstrate changes in the integrity of the blood-brain barrier with ageing, as well as interactive effects with dietary fat. Best of all, they’ve identified some potential restorative approaches that, if successful, could drastically improve the quality of life of people with Alzheimer’s disease and their families.
John and fellow CHIRI researcher Ryu Takechi were awarded the National Health and Medical Research Council’s most prestigious award for having the most potentially innovative and transformative project among grant applications received in 2014, which led to these findings.
The team’s goal is to secure support to put their remedies to the test in major clinical trials.
Research interests – regulation of cerebral capillary integrity in the context of neurodegenerative diseases.