Professor Philip Newsholme
- Vascular and metabolic disorders
- Neurodegenerative disorders
With a research career spanning 32 postdoctoral years and five countries – Australia, Ireland, UK, USA and Brazil – Philip leads a team of CHIRI researchers providing insights into nutrition and metabolism, predominantly in nutritional aspects of age-associated diseases including Type 2 diabetes, chronic inflammation and Alzheimer’s disease.
The team’s recent successes include discovering metabolic reprogramming processes in the insulin secreting pancreatic beta cells which alter the beta cells’ function such that they fail to secrete sufficient insulin, resulting in the disease diabetes.
Using nutritional and pharmaceutical approaches, Philip and his team hope to determine the optimal conditions to improve cellular responses in metabolic disease conditions (diabetes, cardiovascular disease and chronic inflammation) with the goal of hopefully finding an effective strategy to treat or reverse these and other debilitating diseases.
The team’s current research is investigating the role of metabolic reprogramming in pancreatic beta cells and the pathogen detecting and destroying cells known as macrophages in hormone-producing regions of the pancreas called islets. Their goal is to determine the role of inflammation in driving metabolic and secretory changes in hormone-secreting cells, including insulin, glucagon and somatostatin-secreting cells. These changes are responsible for driving physiologic and metabolic responses in the body responsible for diabetes and other related chronic conditions.
Philip’s research group actively collaborates with scientists in Sydney, Australia; Sao Paulo, Brazil; and Aberdeen and Oxford in the United Kingdom.
Research interests – regulation of insulin secretion; insulin action; oxidative stress and diabetes; metabolic reprogramming; lipids and health.